Kinetic optimization of dialysis therapy

Abstract:

The uremic syndrome is still poorly understood at the level of molecular toxicity. Dialysis therapy is largely empirical and based on the hypothesis that the accumulation of water and toxic solutes result in many of the manifestations of the uremic syndrome. The validity of this hypothesis has been demonstrated in part by the fact that dialysis therapy can result in long term amelioration of the uremic syndrome and has become an established therapy for uremia practiced world-wide. However, the uremic syndrome is only partly responsive to «adequate dialysis» and there is variable ongoing morbidity such as anemia, reduced taste and appetite, mild sensory neuropathy, renal osteodystrophy and pruritis in «well dialyzed» patients. There is still substantial intradialytic morbidity with a 10 to 30% incidence of symptomatic hypotension. More recently a frequently disabling syndrome due to beta-2 microglobulin amyloidosis …

Año de publicación:

1990

Keywords:

Fuente:

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