LIVER-ON-A-CHIP: TOWARDS EMULATION OF DRUG METABOLISM IN A MICROFLUIDIC PLATFORM

Abstract:

The drug development process can benefit from the effective screening of toxic metabolites early on. To improve our previous efforts of drug metabolism investigation efforts using enzymatic microfluidic platforms, we have developed a cell-based perfused microfluidic device as a first step towards the drug metabolism mimicry in a chip. Here, we report a liver-on-a-chip device with computational fluid dynamics, cell growth, and assessment of cell functionality results.

Año de publicación:

2021

Keywords:

• microphysiological system
• microfluidic platform
• drug metabolism
• liver-on-a-chip

Fuente:

scopus