Label-free quantification of POEGMA-144 polymerization and thermal response via PC-TIR biosensor

Abstract:

Label-free quantification of polymerization is of significant importance in today's research as recent advancements in the polymer field have sparked numerous applications in the biomedical industry. Poly-((Ethylene Glycol) Methyl Ether)- Methacrylate (POEGMA) has been recognized as a replacement for PNIPAM for biomedical applications due to various factors such as biocompatibility and thermal response rate. With a rapid thermal response, POEGMA allows for a variety of biomedical applications including a potential drug delivery mechanism. In this study, a Photonic Crystal-Total Internal Reflection (PC-TIR) biosensor has been utilized to monitor POEGMA-144, which has been synthesized via an Atom Transfer Radical Polymerization (ATRP) grafting-from approach. Monitoring the optical resonance of this biosensor, it allows for quantification of the growth of a layer of an initiator on the sensor surface as well …

Año de publicación:

2023

Keywords:

Fuente:

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