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Levels, phosphorylation status and cellular localization of translational factor eIF2 in gastrointestinal carcinomas

Abstract:

The level of expression and the phosphorylation status of the α subunit of initiation factor 2 (eIF2α) protein have been determined by comparing samples from human stomach, colon and sigma-rectum carcinomas with normal tissue from the same patients. The unphosphorylated and phosphorylated levels of cytoplasmic eIF2α, as well as the percentage of phosphorylated factor over the total, were significantly higher in stomach, colon and sigma-rectum tumours compared with normal tissue. The expression of this factor was also studied by using immunocytochemical methods, where bkp_redistribution towards the nucleus in tumour cells as compared with normal tissue was observed. Our results support a likely implication of eIF2α in gastrointestinal cancer.

Año de publicación:

2000

Keywords:

    Fuente:

    scopusscopus

    Tipo de documento:

    Article

    Estado:

    Acceso restringido

    Áreas de conocimiento:

    • Biología molecular
    • Cáncer

    Áreas temáticas:

    • Enfermedades

    Contribuidores:

    Redondo C.Redondo C.
    Salinas M.Salinas M.
    Lobo M.Lobo M.
    Monica Isabel PérezMonica Isabel Pérez
    Álvarez M.Álvarez M.
    Alonso F.Alonso F.
    Martín M.Martín M.