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Lipids and lipoprotein (a) in postmenopausal women treated with tibolone.

Abstract:

Objective: To determine modifications in lipids and lipoprotein (a) in postmenopausal women receiving tibolone. Materials and methods: A sample of 45 postmenopausal women who were treated with a dose of 2.5. mg of tibolone daily for 6 months was selected. Serum concentrations of cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), lipoprotein (a) and the cholesterol/HDL and triglyceride/HDL ratios were measured. Results: Cholesterol, triglyceride, LDL-C and lipoprotein (a) concentrations were significantly reduced after 6 months of tibolone use compared with initial concentrations (p<0.05). A statistically significant decrease in HDL-C was observed (p<0.05). The triglyceride/HDL ratio showed a significant reduction of more than 30% (p<0.05). No significant differences in mean cholesterol/HDL ratio values before and after treatment (p=ns) were found. Conclusions: Tibolone significantly reduced cholesterol, triglyceride, HDL-C, LDL-C and lipoprotein (a) concentrations and significant modifications in the triglyceride/HDL-C ratio after 6 months of use. © 2009 Elsevier España, S.L.