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Lipids and lipoproteins concentrations in postmenopausal women treated raloxifene

Abstract:

Objective: To determine cholesterol, triglyceride, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) concentrations in postmenopausal women treated with raloxifene after 3 months of treatment. Methods: Forty-five postmenopausal women were treated with 60. mg/day of oral raloxifene for 3 months. Cholesterol, triglyceride, LDL, and HDL concentrations were assessed. Results: The mean age of the postmenopausal women was 49.3±3.9 years and the mean body mass index was 28.1±3.7. Kg/m2. Follicle-stimulating hormone and estradiol concentrations were 91.7±11.6. UI/ml and 20.1±11.8. pg/ml, respectively. Cholesterol (231.3±36.8. mg/dl at baseline and 216.5±21.3. mg/dl after 3 months) and LDL concentrations (154.6±11.2. mg/dl at baseline and 138.9±14.6. mg/dl after 3 months) were significantly reduced (6% and 10%, respectively) after 3 months of raloxifene use (p<0.05). There were no significant variations in triglycerides or HDL concentrations after raloxifene use (p=ns). Conclusion: Raloxifene use in postmenopausal women significantly reduces cholesterol and LDL concentrations without modifying triglyceride and LDL concentrations after 3 months of treatment. © 2009 Elsevier España, S.L.