Lipoprotein: from a new antigen to a cariovascular risk factor

Abstract:

The lipoprotein (a) discovered by Kare Berg in 1963, has a composition similar to that of low density lipoprotein (LDL). In its structure it also presents apolipoprotein(a), which is bound to apoB-100 by a disulfide bond. One of most Interesting aspects of the biology of Lp(a) is the surprising structural homology that exist between plasminogen and apo(a), knowing itself in addition that the genes for such are located in chromosome 6; this apolipoprotein is also the responsible for the metabolic and biochemical properties of lipoprotein(a). They have been found greater concentrations in masculine sex and subjects of black race, in addition of which certain structural variations exist genetically. Due to its peculiar structure and to the correlation existing between the elevated levels of Lp(a) and the development of atherothrombotic complications, this lipoprotein has become the object of numerous researches, without being …

Año de publicación:

2007

Keywords:

Fuente:

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