Localized excitation of neural activity via rapid magnetothermal drug release


Abstract:

Hysteretic heat dissipation by magnetic nanoparticles (MNPs) in alternating magnetic fields (AMFs) allows these materials to act as local transducers of external stimuli. Commonly employed in cancer research, MNPs have recently found applications in remote control of heat‐dependent cellular pathways. Here, a thermally labile linker chemistry is adapted for the release of neuromodulatory compounds from the surfaces of MNPs via local nanoscale heating. By examining a range of MNP sizes, and considering individual particle loss powers, AMF conditions and nanomaterials suitable for rapid and complete release of a payload from MNP surfaces are selected. Local release of allyl isothiocyanate, an agonist of the Ca2+ channel TRPV1 (transient receptor potential vanilloid cation channel subfamily member 1), from iron oxide MNPs results in pharmacological excitation of neurons with latencies of ≈12 s. When …

Año de publicación:

2016

Keywords:

    Fuente:

    googlegoogle

    Tipo de documento:

    Other

    Estado:

    Acceso abierto

    Áreas de conocimiento:

    • Neurología

    Áreas temáticas de Dewey:

    • Medicina y salud
    • Fisiología humana
    • Otras ramas de la ingeniería
    Procesado con IAProcesado con IA

    Objetivos de Desarrollo Sostenible:

    • ODS 3: Salud y bienestar
    • ODS 10: Reducción de las desigualdades
    • ODS 9: Industria, innovación e infraestructura
    Procesado con IAProcesado con IA

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