METAL MIXTURES EXPOSURE AND CHILD NEURODEVELOPMENT: EVIDENCE FROM RURAL BANGLADESH

Abstract:

Background: Arsenic, manganese and lead exposure are common in Bangladesh. These metals can cross the placenta and are neurotoxic. Limited epidemiologic data currently exists on interactive effects of metal mixtures on child neurocognitive outcomes. Aims: We examined whether exposure to mixtures of arsenic, lead and manganese are associated with neurocognitive outcomes and whether there is evidence of interaction among metals. Methods: Umbilical cord blood samples were collected at delivery from 781 infants in Bangladesh. Whole blood arsenic, lead, and manganese were measured using ICP-MS. Bayley scale of infant development Third Edition (BSID-III) scores were measured at approximately 24 months of age. Associations of cognitive and motor composite scores with lead and manganese concentrations on the logarithmic scale, and arsenic categorized in tertiles, were modeled allowing for …

Año de publicación:

2013

Keywords:

Fuente:

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