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Magnetic SiO <inf>2</inf> -Mn <inf>1-x</inf> Co <inf>x</inf> Fe <inf>2</inf> O <inf>4</inf> nanocomposites decorated with Au@Fe <inf>3</inf> O <inf>4</inf> nanoparticles for hyperthermia

Abstract:

The design of multicore magnetic nanocomposites for hyperthermia therapy is still far from being optimized due to the variable performance found in many iron oxide nanostructure systems. Herein, we present a reproducible synthesis of magnetic mixed manganese-cobalt ferrite nanoparticles Mn 1-x Co x Fe 2 O 4 (0⩽x⩽1) coated with silica (SiO 2 ) and decorated with Au@Fe 3 O 4 nanoparticles as magnetic fluid hyperthermia heat mediators, employing a hydrogel as a tissue-equivalent. Mn 1-x Co x Fe 2 O 4 NPs were synthesized using the thermal decomposition method, then coated with SiO 2 following the Stöber method and decorated with Au@Fe 3 O 4 nanoparticles. Structural characterization was carried out applying X-ray diffraction (XRD), infrared spectroscopy (FTIR), and transmission electron microscopy (TEM). Magnetic properties as a function of the Mn +2 content were studied using a vibrating sample magnetometer (VSM) at room temperature. Hyperthermia investigations were performed at 454±20 kHz with a magnetic field amplitude of up to 5.5 mT. The specific absorption rate (SAR) values of the nanocomposites were found to have increased with the Au@Fe 3 O 4 decoration in water. The advantage of the designed nanocomposite system lies in the fact that versatile combinations of magnetic NPs, SiO 2 and Au@Fe 3 O 4 can change the magnetic properties to optimize the Specific Absorption Rate (SAR).