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Marcadores bioquímicos involucrados en la pbkp_redicción de preeclampsia y su relación con el polimorfismo rs4680 del gen catecol-o-metiltransferasa en circulación fetal.

Abstract:

Background: Investigations have determined that there are several biochemical parameters related to preeclampsia (PE) that would allow raising antecedents for the suspicion of the onset of the disease. Despite this, the idea that the genome plays an important role on the rise or decrease of these biochemical indicators is not rejected. Objective: To establish the relationship between the biochemical markers involved in the pbkp_rediction of severe preeclampsia with the rs4680 polymorphism of the catechol-O-methyl transferase (COMT) gene in the fetal circulation. Methodology: this was a case-control study. For this purpose, blood samples of cryopreserved umbilical cord (artery and vein) of women complicated with severe PE were used (40 cases: artery, n = 20 and vein = 20) and their respective 40 controls (artery, n = 20 and vein, n = 20). DNA was extracted and then the rs4680 polymorphism was amplified. In addition, the levels of several biochemical markers linked to PE in the umbilical artery and vein were measured. The analysis was carried out using the epiinfo ™ 7 statistical package. Results: Lower levels of Placental Growth Factor and higher levels of protein A associated with pregnancy and free β-human chorionic gonadotropin (in vein and umbilical artery) were found in cases compared to controls. There was a non-significant trend in the umbilical vein of lower levels of Placental Growth Factor (pg / mL) and higher protein A associated with pregnancy and free β-human chorionic gonadotropin levels according to the genetic variants of the rs4680 polymorphism. Conclusion: The levels of biochemical markers showed differences in relation to the gene variants of the rs4680 polymorphism, although these were not significant, possibly due to the sample size. More research is required in this regard.