Materials at the Interface Tissue-Implant A Focus on Regeneration

Abstract:

Humans have been using surgical implants since ancient history but their use has increased substantially in the last few decades. Regardless of their purpose, all implants create an interface between the biological underlying tissue and the surface of the implant material. While there has been an increased use of small temporary implants that are biodegradable and then dissolve in the body after a short period of time, the vast majority of surgical implants are still made of non-biodegradable materials. From hip prostheses to peritoneal catheters, the presence of an abiotic interface induces a well studied foreign body response. The failure of this biointerface has prevented the extended use of advanced prosthetics and the development of biointegrated devices with new capabilities, limiting the usefulness of the implants and causing significant health care costs and patient morbidity. In this monograph I will describe how a focus on the use of implant biomaterials with regenerative properties may help improve the integration of the implants with the tissues and reduce implant failure. © 2012 Scrivener Publishing LLC. All rights reserved.

Año de publicación:

2012

Keywords:

• chemical composition
• Regenerative biomaterials
• biopolymers
• Tissue-implant interface
• Tissue damage

Fuente:

scopus