A Low Exhaled Nitric Oxide Level Excludes a Short-Term Benefit from Inhaled Corticosteroids in Suspected Asthma

Abstract:

Rationale: Fractional exhaled nitric oxide (FeNO) is a non-invasive biomarker that has been used to guide inhaled corticosteroid (ICS) treatment in asthma. We have previously shown in an observational study that a FeNO< 27 ppb provided the best cut point to identify ICS nonresponders1. The purpose of this study was to determine if a low FeNO (< 27 ppb) could be used to reliably identify patients with suspected asthma who would not benefit from starting treatment with an ICS. Methods: 180 steroid naïve adult patients with suspected asthma and a FeNO of< 27ppb were randomized to receive either 400mcgs of budesonide or placebo daily. Patients were followed-up every four weeks for three months. The primary outcome was the difference in the Asthma Control Questionnaire 7 (ACQ7) between active and placebo groups. The change in ACQ7 was assessed using a two, one-sided test (TOST) with a difference …

Año de publicación:

2019

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Fuente:

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