Modeling and simulation of the cardiovascular system maternal-fetal

Abstract:

This article presents a mathematical model that attempts to simulate simultaneous mother and fetus cardiovascular systems response, at the end of the gestational period. Physiologic remodeling of the mother's cardiovascular system (SCM) takes place during pregnancy, involving increases in Heart Rate (FC), Stroke Volume (VL), and Cardiac Output (GC) along with a decrease in Total Peripheral Resistance (RPT), without apparent changes in the Mean Arterial Pressure (PAM); while fetal cardiovascular system (SCF) is developing to satisfy fetal necessities, experiencing physiologic and anatomical modifications. The proposed model is a simple compartmental system of closed circulation composed by 14 vascular segments. The Mother's side includes a controller of arterial pressure effect (baroreceptor system) which can be simulated as proportional or as adaptive. The computer simulations were carried out by implementing the set of dynamic equations using block diagrams in Simulink®. The overall model was run under resting basal conditions of a mother with is byproduct at the end of the gestational period using both control laws. Model validation was carried out by comparing simulated responses with the literature as well as those of a set of twenty mothers measured in a clinical setting, using a t-test. Finally, another five mothers with HTAIE were measured and mimic conditions were simulated. Simulation results were in agreement with published and experimental data for mothers and fetus at the end of the gestational period. In conclusion, the proposed model is a good tool to simulated simultaneous mother and fetus cardiovascular systems response, at the end of the gestational period. © Springer-Verlag Berlin Heidelberg 2007.

Año de publicación:

2008

Keywords:

Fuente:

scopus