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Modification of medical grade silicone with stimuli-responsive acrylic/methacrylic polymers for ciprofloxacin delivery, their antimicrobial activity and biocompatibility

Abstract:

Polymeric medical devices have become essential for healthcare because of their advantageous characteristics; however, by themselves, these polymers cannot stop pathogenic contamination. Since this is an important unresolved issue, this work proposes the study of the loading and release of ciprofloxacin, a broad-spectrum antibiotic onto polyacrylic acid/polyethylene glycol dimethacrylate (AAc/EGDMA) modified PDMS films. Effective loading and release of the antibiotic was studied by UV–Vis experiments verifying kinetics following the Peppas–Sahlin model of release for ciprofloxacin. Additionally, the films were tested in cell growth inhibition tests and cytotoxicity assays in which they showed effective inhibition of E. coli while also maintaining good cytocompatibility. Graphic abstract: [Figure not available: see fulltext.]