Molecular analysis in true hermaphrodites with different karyotypes and similar phenotypes

Abstract:

Male sex determination in mammals depends on the presence of a Y chromosome and the testicular determining factor (TDF)[Welshons and Russell, 1959; Page et al., 19871. TDF was first located in the interval 1Al on the Y chromosome, and the candidate gene was named ZFY [Page et al., 19871. However, subsequently it was redefined in a 35 kb segment on the distal region of the short arm of the Y chromosome, proximal to the pseudoautosomal boundary. The gene found in this location is known as SRY (sex-determining region on Y chromosome)[Sinclair et al., 19901. True hermaphroditism is a clinical condition in which ovarian and testicular tissues are present in the same individual, either in separate gonads or in one gonad (ovotestis)[van Niekerk and Retief, 19811. These subjects usually present ambiguous external genitalia, whereas the development of Wolffian and Miillerian duct derivatives depends …

Año de publicación:

1996

Keywords:

Fuente:

google