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Multi-target inhibitors for proteins associated with Alzheimer: In silico discovery using fragment-based descriptors

Abstract:

Alzheimer disease (AD) is one of the most common and serious neurodegenerative disorders in humans. For this reason, the search for new anti-AD treatments is a very active area. Only few biological receptors associated with AD have been well studied. The efficacy of the current drugs is limited by the fact that they inhibit only one target like protein. Thus, the rational design of new drug candidates as versatile inhibitors for different proteins associated with AD, constitutes a major goal. With the aim to overcome this problem, we developed here the first fragment-based approach by exploring quantitative-structure-activity relationships (QSAR). The principal purpose was the in silico design of multitarget (mt) inhibitors against five proteins associated with AD. Our approach was focused on the construction of an mt-QSAR discriminant model using a large and heterogeneous database of compounds and substructural descriptors, which permitted the simultaneous classification and pbkp_rediction of inhibitors against five proteins associated with AD. The model correctly classified more than 90% of active and inactive compounds in both, training and pbkp_rediction series. As principal advantage, this mt-QSAR discriminant model was used for the automatic and fast extraction of fragments responsible for the inhibitory activity against the five proteins under study, and new molecular entities were suggested as possible versatile inhibitors for these proteins. © 2013 Bentham Science Publishers.