Multiple Drug Hypersensitivity Syndrome In Our Allergy Service

Abstract:

Methods We analyzed retrospectively all patients with a confirmed diagnosis of drug hypersensitivity evaluated in our allergy department between January 2005 and December 2010. Results A MDH was diagnosed in 48 (2.41%) of the 1989 patients evaluated, being 32 females, with a mean age of 50±14, 43 years. A total of 137 episodes were reported: 80 (58, 39%) suggested an IgE-mediated reaction, 37 (27%) a non-immunologic mechanism (cross-reactive to NSAIDs) and 20 (14, 55%) a T-cell mediated reaction. The percentage of MHD in patients with IgE-mediated reactions (9, 78%) was higher compared to those with T-cell mediated reactions (5, 23%) and non-immunologic reactions (1, 91%)(p< 0, 0001). The drugs most frequently involved were dypirone (13, 6%), ciprofloxacin (12, 1%), amoxicillin-clavulanic acid (11, 4%), amoxicillin (10%), ASA (8, 6%), ibuprofen (7, 1%) and moxifloxacin (5, 7%). Sensitivity …

Año de publicación:

2014

Keywords:

Fuente:

google