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Myeloid hypoxia-lnducible factors in inflammatory diseases

Abstract:

Hypoxia inducible factors (HIFI and HIF2) have emerged as central regulators of the activity of myeloid cells at inflammatory sites where 02 is frequently limited. Novel insights in the field have revealed that the expression of FfiFs by myeloid cells is not exclusively induced by hypoxia but also in response to central inflammatory mediators independently of 02 shortage. This has substantially elevated the biological significance of FfiFs in the context of inflammatory diseases. As a consequence, the loss of FfiFl or E1IF2 in myeloid cells specifically compromises some of the processes driven by myeloid cells, such as bactericidal activity and myeloid invasion, as well as inflammation-associated detrimental consequences. © 2011 by Begell House, Inc.