NO as temporary guanidino-protecting group provides efficient access to Pbf-protected argininic acid

Abstract:

Pbf-protected argininic acid [H-OArg(Pbf)-OH], a building block for Fmoc-solid phase peptide synthesis, is obtained in high yield when a large excess of nitrosating agent is used in conjunction with intermediate N δ-nitrosyl protection and Nδ-denitrosation in aqueous acidic medium. © 2005 Elsevier Ltd. All rights reserved.

Año de publicación:

2005

Keywords:

• Solid phase peptide synthesis
• Depsipeptides
• side-reactions
• arginine

Fuente:

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