Nanoparticles functionalized for target delivery of siRNA in lung cancerous cells

Abstract:

In the present medical field, scientists have designed new techniques to improve human health. These techniques focus on molecular level controls. Small interference RNA is an example of genetic control. This, together with Dicer and Argonaute 2 do not allow the transcription process to synthesize new protein. By using this mechanism, it is possible to control some diseases that are responsible for metastasis, such as lung cancer. Some experiments were conducted to prove the effectiveness of this technique. However, the problem is how to introduce the double-strand RNA to the cells. The issue was solved using nano-carriers as NP's. This paper aims at making a brief review of lung cancer, siRNA mechanism, and some different targeting techniques.

Año de publicación:

2020

Keywords:

• DSRNA
• Nanoparticles
• lung cancer
• siRNA
• AGO2-Dicer complex

Fuente:

scopus