Neural sources from resting state eeg oscillations in angelman syndrome

Abstract:

Angelman syndrome (AS) is a neurodevelopmental genetic disease due to deficient UBE3A expression. We recorded and analyzed high density electroencephalogram (128 electrodes) by signal averaging and EEG inverse solution model estimation in 6 children with AS (aged 2-5) while in a default-mode (resting state). We found a consistent theta oscillation (5Hz) originating in somatosensory associative cortex (BA7) that could be explained by the contribution of the hippocampal network able to produce theta oscillation on the cortical mantle. We hope this new approach can be used to better understand the origin of the emergence of recurrent theta oscillations in AS patients. Résumé en Français: Titre: Enregistrement de l’activité cérébrale des patients souffrant du syndrome d’Angelman Le syndrome d’Angelman est une affection génétique qui perturbe le développement du cerveau menant à un retard mental …

Año de publicación:

2016

Keywords:

Fuente:

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