Neuropeptide Y-induced inositol phospholipid hydrolysis in blood vessels from normotensive and spontaneously hypertensive rats

Abstract:

1. 1. Neuropeptide Y (NPY) increased inositol phosphate (IP) formation in the femoral artery and vein of adult Wistar Kyoto (WKY) and spontaneously hypertensive (SHR) rats. 2. 2. Noradrenaline (NA, 10-6 M induced IP accumulation in both strains of rats. 3. 3. Subthreshold concentrations of NPY (3 × 10-9 M for femoral vein and 10-8 M for femoral artery) failed to modify NA (10-6 M)-induced IP formation in both vessels. 4. 4. These results suggest that the direct contractile effects but not the potentiation of NA-induced contractions may be directly linked to phosphatylinositol turnover in adult SHR and WKY rats. © 1993.

Año de publicación:

1993

Keywords:

Fuente:

scopus