New cytotoxic isoflavone from the root bark of Brosimum utile


Abstract:

A new isoflavone 5,7,4′-trihydroxy-3′-(3-hydroxy-3-methylbutyl)isoflavone (isowigtheone hydrate) (1), together with six known isoflavones 2-7 and (-)epicatechin, were isolated from the root barks of Brosimum utile. Their structures were established on the basis of spectroscopic evidence. The in vitro cytotoxic activity of the new compound 1 was evaluated against cell lines MCF7 (human breast carcinoma), PC3 (human prostate carcinoma), HT29 (human colon cancer) and human dermis fibroblasts. © 2005 Taylor & Francis Group Ltd.

Año de publicación:

2005

Keywords:

  • Cytotoxic
  • Isiowigtheone hydrate
  • Isoflavone
  • Moraceae
  • Brosimum utile

Fuente:

scopusscopus

Tipo de documento:

Article

Estado:

Acceso restringido

Áreas de conocimiento:

  • Bioquímica
  • Farmacología

Áreas temáticas:

  • Farmacología y terapéutica