New cytotoxic isoflavone from the root bark of Brosimum utile
Abstract:
A new isoflavone 5,7,4′-trihydroxy-3′-(3-hydroxy-3-methylbutyl)isoflavone (isowigtheone hydrate) (1), together with six known isoflavones 2-7 and (-)epicatechin, were isolated from the root barks of Brosimum utile. Their structures were established on the basis of spectroscopic evidence. The in vitro cytotoxic activity of the new compound 1 was evaluated against cell lines MCF7 (human breast carcinoma), PC3 (human prostate carcinoma), HT29 (human colon cancer) and human dermis fibroblasts. © 2005 Taylor & Francis Group Ltd.
Año de publicación:
2005
Keywords:
- Cytotoxic
- Isiowigtheone hydrate
- Isoflavone
- Moraceae
- Brosimum utile
Fuente:
scopus
Tipo de documento:
Article
Estado:
Acceso restringido
Áreas de conocimiento:
- Bioquímica
- Farmacología
Áreas temáticas:
- Farmacología y terapéutica