New derivatives of 6-phenylcomanic acid

Abstract:

Ethyl 6-phenylcomanic acid with hydrazine hydrate and hydroxylamine gives 4-oxo-6-phenyl-4H/-pyran-2-carbohydrazide and 4-oxo-6-phenyl-4H-pyran-2- carbohydroxamic acid, whereas 6-phenylcomanic acid with ammonia in aqueous DMSO gives 4-hydroxy-6-phenylpicolinic acid, converted further to its ethyl ester and hydrazide. The reaction of 6-phenylcomanic acid with phenylhydrazine gives rise to 3-(1,5-diphenyl-1H/-pyrazol-3-yl)-2-(2-phenylhydrazono)propionic acid, which by the Fischer reaction was converted to 3-(1,5-diphenyl-1H-pyrazol-3-yl)-1H- indole-2-carboxylic acid. © ; 2009 Springer Science+Business Media, Inc.

Año de publicación:

2009

Keywords:

• Fischer indole synthesis
• 6-phenylcomanic acid and its derivatives
• Phenylhydrazine
• 4-hydroxy-6-phenylpicolinic acid and its derivatives

Fuente:

scopus