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New manufacturing process to produce highly uniform resins with excellent performances in Solid Phase Peptide Synthesis

Abstract:

Peptides are an important class of Active Pharmaceutical Ingbkp_redients. Thanks to the implementation of the solid phase synthesis methodology pioneered by the Nobel Laureate R. Bruce Merrifield in the 20th century, it is now possible to synthesize peptides with up to forty amino acids in a multi- kilogram scale. Herein, we describe a new manufacturing process to produce highly uniform resins that can be successfully applied to solid phase peptide synthesis (SPPS). The resins were employed for the synthesis of between 5 and 28mer peptides using either automatic heat-assisted microwave systems or manual mode. Excellent results are reported when PuroSynth™ CTC/S, PuroSynth™ Wang/S, PuroSynth™ Rink Amide/S and PuroSynth™ MBHA/S are used for SPPS.