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New molecular approaches in adipogenesis regulation: The connexin 43 role

Abstract:

The global prevalence of obesity has been increased rapidly over the past few years mainly due to changes in the lifestyle of the population with a significant increase in energy consumption and decreased levels of physical activity. As a result, the scientific community is interested in a deeper understanding of the mechanisms that regulate the pathophysiology of obesity. In this context, adipogenesis process is an important target of study to understand the obesity and associated pathologies. Recently has been emerged important evidence that involve gap junction channel protein connexin 43 (C×43) in the regulation of processes related to adipogenesis, whose role is fundamentally anti-adipogenic. However, new functions of C×43 in the regulation of adipose tissue function also continued to emerge.