New oxapolycyclic cage amines with NMDA receptor antagonist and trypanocidal activities

Abstract:

The synthesis of several (1,2,3,5,6,7-hexahydro-1,5:3,7-dimethano-4-benzoxonin-3-yl)amines and related compounds is reported. Several of them display very similar activity to memantine as NMDA receptor antagonists. Several derivatives showed a significant level of trypanocidal activity. © 2009 Elsevier Ltd. All rights reserved.

Año de publicación:

2010

Keywords:

• Polycyclic cage compounds
• Amantadine
• NGP1-01
• Memantine
• Trypanosoma
• NMDA
• Indantadol

Fuente:

scopus