New treatments based on gene therapy approaches to increase radiosensitisation in prostate cancer.

Abstract:

Radical prostatectomy, hormonal therapy and radiation are conventional techniques for eradicating prostate cancer. When surgery is not a therapeutic choice, or tumour does not respond to hormonal therapy with local symptoms on the primary or metastatic foci, radiation is used as the last treatment line for these patients. Our approach for increasing the radiosensitisation of prostate tumour cells is based on the overexpression into the tumour cells of the bacterial enzyme cytosine deaminase (CD) by gene transfer techniques. This enzyme (CD) can specifically transform the non-toxic pro-drug 5flurocytosine (5-FC) into the toxic compound 5-fluorouracil (5-FU). It is well established that 5-FU is an enhancer radiosensibilisator.

Año de publicación:

2000

Keywords:

Fuente:

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