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A Multiplatform Non-targeted Metabolomics Approach to Investigate Insulin Resistance Associated to Obesity in Childhood

Abstract:

• The use of metabolomic techniques could be a suitable approach to investigate the relationship between obesity and IR. Increased fasting or post-OGTT glucose levels are used for the diagnosis of obesity-associated carbohydrate metabolism impairment in adults. However, in obese children hyperinsulinism as a consequence of insulin resistance (IR) is usually found much earlier than the rise in glycemia. In childhood obesity, huge variations in fasting and postprandial insulinemia are observed for a given BMI, even in age, sex and ethnic controlled comparisons. This suggests the existence of predisposing factors for obesity associated IR that remain unclear to date.