New use of bis(benzotriazolyl)-1,2-(dialkylamino)ethanes for the synthesis of 2-H-3-dialkylamino imidazo[1,2-a]pyrazine derivatives

Abstract:

First direct synthesis of 2-H-3-N-dialkyl-imidazo[1,2-a]pyrazines is described. This approach makes use of accessible substituted pyrazines and the assistance of benzotriazole. In such a manner we accomplished the introduction of cyclic amines at C-3 of the scaffold in a convenient formal cyclisation procedure. Detailed examples and utility of this approach are presented herein. © 2011 Elsevier Ltd. All rights reserved.

Año de publicación:

2012

Keywords:

• One pot cyclisation
• Benzotriazole
• 2-H-3-N-Dialkyl-imidazo[1,2-a]pyrazines synthesis

Fuente:

scopus