O2‐13‐04: Insulin‐like growth factor binding protein‐2 in relation to cognition and Alzheimer's disease biomarkers

Abstract:

Background Insulin-like growth factor binding protein-2 (IGFBP-2) is the most abundant of binding proteins in the brain. IGFBP-2 increases after age 60, yet relations among IGFBP-2, cognition, and AD biomarkers have not been thoroughly investigated. The current study investigated the association of IGFBP-2, cognition, and AD biomarkers among elders with normal cognition (NC), mild cognitive impairment (MCI), and Alzheimer's disease (AD). Methods Baseline Alzheimer's Disease Neuroimaging Initiative data were accessed for NC, MCI, and AD participants (n= 346, 75±7 years, 38% female), including IGFBP-2, memory and executive function composite scores derived from baseline and longitudinal neuropsychological data, and cerebrospinal fluid (CSF) AD biomarkers, including total tau, phosphorylated tau, and amyloid beta. Analysis of variance evaluated diagnostic group differences in IGFBP-2. Mixed effects …

Año de publicación:

2015

Keywords:

Fuente:

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