O3‐10‐02: Clinician staging of mild cognitive impairment severity yields neuropsychological, neuroimaging, and genetic susceptibility differences among subtypes: The vanderbilt …

Abstract:

Background Despite limited empirical validation, recent efforts have dichotomized mild cognitive impairment (MCI) severity into early and late stages. Given the heterogeneity of MCI clinical severity and prognosis, this study assessed whether clinician-driven MCI staging (early, middle, and late) corresponded to neuropsychological, neuroimaging, or genetic susceptibility differences. Methods Participants were drawn from the Vanderbilt Memory & Aging Project, a case control longitudinal study investigating vascular health and brain aging. At screening, participants were diagnosed with MCI via consensus based on comprehensive visit results. Using this information, clinicians further categorized MCI participants into three severity subtypes, including early (n= 60, 72±7 years, 43% female), middle (n= 83, 72±7 years, 40% female), and late stage (n= 20, 78±7 years, 40% female). At enrollment, participants completed …

Año de publicación:

2015

Keywords:

Fuente:

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