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Obtention of pharmaceutical quality raw material from Justice pectoralis Jarq. Extracts, by spray dried. Technology development from a 30% hydroalcoholic extract

Abstract:

Justicia pectoralis Jacq. (Acanthaceae) is an herbaceous plant which has been traditionally used by the Cuban peoples due to it's sedative properties. To obtain a pharmaceutical quality raw material in dried extract form, 30% hydroalcoholic extracts of Justicia-pectorialis were spray dried and stability and pharmacological studies were carried out. Results showed that the developed technology was right to obtain a pharmaceutical quality raw material, which presents the characteristic of being highly hygroscopic, being affected by light and heat. Pharmacological assays carried out with the dried extract obtained and administered orally showed sedative activity in a dose dependent pattern in induced aggressiveness in isolated animals model and the exploratory activity model in doses of 5, 20 and 80 mg/kg of corporal weight. It was also observed a dose-dependent effect in the barbiturate induced dream model when the dry extract was applied. All these results confirm that the sedative effect of the studied material was not affected by the technological process developed.