Optimized metal-organic-framework based magnetic nanocomposites for efficient drug delivery and controlled release

Abstract:

Metal organic framework (MOF) has attracted wide attention as a promising biological platform due to its distinctive characteristics such as large surface areas, tunable pore sizes, and high selectivity in small molecule uptake. The incorporation of other guest materials into MOFs has resulted in additional functionalities of the conjugated MOF-composites. In this work, we have successfully conjugated Fe3O4 magnetic nanoparticles with MIL-88B–NH2 MOF structures using optimized synthetic media containing acetic acid as a modulating agent and F127 co-polymer as a stabilizing agent, which result in a well-controlled hybrid magnetic nanocomposite with an average size of 117 nm. This unique hybrid material has been further utilized as a nanocarrier for efficient drug delivery with the capability of on-demand controlled drug release. Glioblastoma drugs, including Carmustine (BCNU) and Mertansine (DM1), have …

Año de publicación:

2022

Keywords:

Fuente:

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