Optimized synthesis of aminooxy-peptides as glycoprobe precursors for surface-based sugar-protein interaction studies

Abstract:

An improved procedure for solid phase coupling of Boc-aminooxyacetic acid to peptides is described. By avoiding base-containing activation mixtures which cause over-acylation, it practically suppresses this unwanted side reaction and leads to near quantitative yields of Aoa-peptides, useful as glycoprobe precursors in glycomic studies. © 2007 Elsevier Ltd. All rights reserved.

Año de publicación:

2007

Keywords:

• Surface-based interaction studies
• coupling reagent
• Aminooxy-peptide
• Glycoprobes

Fuente:

scopus