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Osteoporosis in a 30-yr old woman with premature ovarian insufficiency. Case report

Abstract:

Introduction: Osteoporosis is a multifactorial disease of the skeleton generally asymptomatic, characterized by low bone mass and impaired bone microarchitecture with increased fragility thereof and consequent tendency to fractures, whose genesis contribute to genetic and environmental factures. Case Description: The present case concerns a 30 year old woman, G4-C3-A1, presenting with amenorrhea of 5 years and vasomotor symptoms of great importance for which the respective studies were preformed. Laboratory report: FSH mIU/L, LH 34.3 mIU/L, Progesterone 0.05 ng/mL. Transvaginal ultrasound reports atrophied uterus and ovaries, which at first suggests early ovarian failure, which is directly linked to osteoporosis. Bone Mass Densitometry reports: T score -2.9 and Z score -1.8 in the spine, while T score -1.7 and Z score -0.7 on hips, corresponding to osteoporosis spine and hip osteopenia respectively. She was treated with cyclic combined hormone therapy treatment, ibandronic acid, calcium citrate and modification of life style. Discussion: Menopause is the main cause of osteoporosis in women due to declining estrogen levels physiologically or by surgical removal of the ovaries. Women who go through menopause early so are nearly twice as likely to suffer from osteoporosis, thus increased risk of fractures and increased mortality rate.