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Oxyma-T, expanding the arsenal of coupling reagents

Abstract:

Herein, we report a new oxime-based additive (Oxyma-T) with a similar structure to HONM and Oxyma-B for use in peptide synthesis. Oxyma-T produces less racemization than HOBt, HOAt, OxymaPure, and Oxyma-B during the stepwise solution-phase synthesis of Z-Phg-Pro-NH2. Moreover, it exhibits superior coupling efficiency in comparison to HOBt during the SPPS of an Aib-enkephalin pentapeptide. Racemization during segment coupling follows the order: HOBt > Oxyma-T > OxymaPure > HOAt > Oxyma-B.

Año de publicación:

2016

Keywords:

  • Solid-phase peptide synthesis
  • Peptide coupling reagent
  • Oxime
  • Carbodiimides/additives
  • Solution-phase peptide synthesis

Fuente:

scopusscopus

Tipo de documento:

Article

Estado:

Acceso restringido

Áreas de conocimiento:

  • Síntesis química
  • Ingeniería química

Áreas temáticas:

  • Química física

Contribuidores:

Govender T.Govender T.
El-Faham A.El-Faham A.
Alberício F.Alberício F.
Kruger H.G.Kruger H.G.
B. G. De la TorreB. G. De la Torre
Jad Y.E.Jad Y.E.