P-Nitrobenzenesulfonamides and their fluorescent dansylsulfonamides derived from N-alkylated o-(purine-methyl)anilines as novel antitumour agents

Abstract:

We have designed and synthesized a novel series of fourteen alkylated purines with notable in vitro anti-proliferative activities against three cancerous cell lines. In vivo studies show absorption by the oral route of administration with systemic distribution and low toxicity for the two more active derivatives.

Año de publicación:

2015

Keywords:

Fuente:

scopus