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P1‐023: CEREBROSPINAL FLUID AND PLASMA NEUROFILAMENT LIGHT ELEVATIONS CORRESPOND TO WORSE COGNITIVE PERFORMANCE IN AGING ADULTS

Abstract:

Background Axonal damage may contribute to cognitive changes preceding clinical dementia. Neurofilament light (NFL) is a well-established protein marker for axonal injury, with elevated cerebrospinal fluid (CSF) concentrations reported in individuals with mild cognitive impairment (MCI) and Alzheimer's disease. Emerging data suggest NFL can also be reliably measured in plasma, but its clinical correspondence with early, subtle age-related cognitive changes has not yet been characterized. The purpose of this study was to relate plasma and CSF NFL to neuropsychological performance among community-dwelling older adults with normal cognition (NC) and MCI. Methods Vanderbilt Memory & Aging Project participants ranging from NC to MCI were studied (plasma n= 333, 73±7 years; CSF n= 149, 72±6 years). Participants underwent fasting venous blood draw, lumbar puncture for CSF acquisition, and …

Año de publicación:

2019

Keywords:

    Fuente:

    googlegoogle

    Tipo de documento:

    Other

    Estado:

    Acceso abierto

    Áreas de conocimiento:

    • Neurología
    • Neuropsicología

    Áreas temáticas:

    • Enfermedades
    • Fisiología humana
    • Procesos mentales conscientes e inteligencia

    Contribuidores:

    Jefferson Michael Acosta OrtizJefferson Michael Acosta Ortiz