P1‐323: Comparison of Hippocampal Segmentation Methods to Differentiate Participants with Mild Cognitive Impairment and Normal Cognition: The Vanderbilt Memory and Aging Project

Abstract:

Background Hippocampal atrophy on magnetic resonance imaging (MRI) is a common marker of neurodegeneration and Alzheimer’s disease. This study compared 4 common methods for quantifying hippocampal volume (ie, 3 automated segmentation techniques and manual tracing, the gold standard) in differentiating participants with mild cognitive impairment (MCI) and normal control (NC). Methods Data were drawn from the Vanderbilt Memory & Aging Project, a case-control longitudinal study, including 65 MCI (76±8 years, 38% female) and 28 NC (76±8 years, 30% female) participants. At baseline, hippocampal volume was quantified from T1-weighted isotropic 1mm 3 images acquired on a 3T Phillips Achieva scanner. A board-certified neuroradiologist blinded to clinical information completed manual tracings. Manual tracing reliability statistics were calculated on 10-double coded images. Automated …

Año de publicación:

2016

Keywords:

Fuente:

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