P2‐456: CEREBRAL BLOOD FLOW AND CEREBROVASCULAR REACTIVITY PREDICT COGNITIVE TRAJECTORY IN OLDER ADULTS

Abstract:

Background Cerebral blood flow (CBF) and cerebrovascular reactivity (CVR) changes precede clinical dementia. However, it is unclear how CBF and CVR relate to memory trajectory, particularly among carriers of APOE-ε4, a molecular modifier of vascular disease and strong genetic risk factor for Alzheimer's disease (AD). Methods Vanderbilt Memory & Aging Project participants free of clinical stroke or dementia (n= 282, 73±7 years, 40% female) underwent T1-weighted magnetic resonance imaging (MRI) to quantify gray matter volume, pseudo-continuous arterial spin labeling MRI to measure resting CBF (mL/100g/min) and hypercapnia-induced CVR, and longitudinal neuropsychological assessment at baseline, 18-month, and 36-months. Linear regressions related baseline regional CBF and CVR to longitudinal cognitive trajectory across 36 months, adjusting for age, sex, race/ethnicity, education, Framingham …

Año de publicación:

2018

Keywords:

Fuente:

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