P3-297 SUBJECTIVE COGNITIVE DECLINE AND NEUROIMAGING AND CEREBROSPINAL FLUID MARKERS OF CEREBROVASCULAR HEALTH: THE VANDERBILT MEMORY AND AGING PROJECT

Abstract:

Background: The sleep disturbance has been reported as one of the risk factors for neurodegenerative diseases. It is not clear that which cognitive processes are more vulnerable to sleep disturbance in the elderly with or without cognitive dysfunction. The aim of this study is that to investigate which cognitive processes are specifically related to the poor sleep quality in the patients with the subjective memory impairment (SMI) and amnestic mild cognitive impairment (aMCI). Methods: One hundred forty-five patients with SMI and 128 patients with aMCI were participated in this study. All participants performed the Pittsburgh Sleep Quality Index (PSQI) and divided into good sleeper (PSQI< 5) and bad sleeper (PSQI 5) with the global PSQI score. The comprehensive neuropsychological tests were addressed for evaluating attention (digit span forward & backward), language (Korean version of Boston Naming Test), visuospatial function (Rey Complex Figure Test; RCFT), verbal memory (Seoul Verbal Learning Test; SVLT, 3 trials of learning, delayed recall, and recognition), visual memory (RCFT immediate recall, delayed recall, and recognition), and executive function (Controlled Oral Word Association Test; COWAT, Stroop Color Reading, Trail Making Test part B, Digit Symbol Coding). The Short form of Geriatric Depression Scale (SGDS) was used for evaluating depressive symptomatology. Results: In the patients with SMI, there was no significant difference between the good sleepers and bad sleepers in the demographic data and neuropsychological tests. However, the bad sleepers of SMI showed higher score in the SGDS than good sleepers. In …

Año de publicación:

2017

Keywords:

Fuente:

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