P3‐137: THE ASSOCIATION BETWEEN TELOMERE LENGTH AND COGNITIVE FUNCTION IS MODIFIED BY BIOMARKERS OF ALZHEIMER'S DISEASE

Abstract:

Background Telomere shortening is a marker of cellular aging and may play a role in age-related neurodegenerative diseases, such as Alzheimer's disease (AD). However, there are conflicting reports in the literature regarding the effect of telomere shortening on cognitive function, especially in the context of AD pathogenesis. This study aimed to correlate telomere length to cognitive function. Moreover, we evaluated whether associations between telomere length and cognition were modified by evidence of AD pathology. Methods Our analysis consisted of 524 participants from the AD Neuroimaging Initiative (ADNI), including 174 with normal cognition, 317 with MCI, and 32 with AD. They had a mean baseline age of 74.8 and 46% were female. Telomere lengths of genomic DNA isolated from circulating leukocytes were measured using quantitative PCR. We analyzed associations between telomere length and …

Año de publicación:

2019

Keywords:

Fuente:

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