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P3‐248: Lower Values of Hemoglobin and Hematocrit Relate to Increased Cerebral Blood Flow in Older Adults with Normal Cognition and Mild Cognitive Impairment: the Vanderbilt …

Abstract:

Background Arterial spin labelling (ASL) MRI is a common method for measuring cerebral blood flow (CBF) across a range of neurodegenerative and cerebrovascular disorders. Adequate tissue oxygenation is dependent on blood flow and the oxygen-carrying capacity of hemoglobin. Increased CBF and velocity has been demonstrated in hereditary anemias, but associations between values of hemoglobin, hematocrit and CBF have not been demonstrated in older adults without dementia. Methods Participants with normal cognition (n= 157, 58% male, 72.5±7 years) and mild cognitive impairment (n= 163, 59% male, 73.2±7 years) were drawn from the Vanderbilt Memory & Aging Project, a case-control cohort. Whole blood hemoglobin (g/dL) and hematocrit (%) values were quantified using automated cell counter methods. Pseudo-continuous ASL assessed CBF measuring the rate of blood delivery to tissue (mL …