P3‐248: Lower Values of Hemoglobin and Hematocrit Relate to Increased Cerebral Blood Flow in Older Adults with Normal Cognition and Mild Cognitive Impairment: the Vanderbilt …

Abstract:

Background Arterial spin labelling (ASL) MRI is a common method for measuring cerebral blood flow (CBF) across a range of neurodegenerative and cerebrovascular disorders. Adequate tissue oxygenation is dependent on blood flow and the oxygen-carrying capacity of hemoglobin. Increased CBF and velocity has been demonstrated in hebkp_reditary anemias, but associations between values of hemoglobin, hematocrit and CBF have not been demonstrated in older adults without dementia. Methods Participants with normal cognition (n= 157, 58% male, 72.5±7 years) and mild cognitive impairment (n= 163, 59% male, 73.2±7 years) were drawn from the Vanderbilt Memory & Aging Project, a case-control cohort. Whole blood hemoglobin (g/dL) and hematocrit (%) values were quantified using automated cell counter methods. Pseudo-continuous ASL assessed CBF measuring the rate of blood delivery to tissue (mL …

Año de publicación:

2016

Keywords:

Fuente:

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