P3‐284: Lower Cardiac Index Levels Relate to Reduced Cerebral Blood Flow Values in Older Adults with Normal Cognition and Mild Cognitive Impairment: the Vanderbilt Memory and …

Abstract:

Background Mechanisms underlying reported associations between lower cardiac index and smaller brain volume, increased white matter hyperintensities, worse cognitive performance and incident dementia are not well understood. We hypothesized that lower systemic cardiac index is associated with lower cerebral blood flow (CBF) among older adults without dementia. Methods Participants with normal cognition and mild cognitive impairment (n= 318, 73±7, 59% male) were drawn from the Vanderbilt Memory & Aging Project, a case control longitudinal study. Cardiac index ((stroke volume x heart rate)/body surface area, L/min/m 2) was quantified from echocardiography. CBF, the rate of blood delivery to tissue (mL blood/100g tissue/min), was assessed with pseudo-continuous arterial spin labeling MRI. Linear regression models with ordinary least square estimates related cardiac index to CBF regions of interest …

Año de publicación:

2016

Keywords:

Fuente:

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