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P3‐350: INFLUENCE OF MEDICAL COMORBIDITIES ON BIOMARKER‐INFORMED COGNITIVE RESERVE IN OLDER ADULTS

Abstract:

Background Cognitive reserve (CR) is a theoretical construct that describes a person's capacity to function cognitively relative to the extent of underlying brain pathology. CR can be operationalized as the deviation in a person's capacity to perform a cognitive task relative to their level of pathology. Previous studies have indicated that CR is associated with education, IQ, and other socioeconomic factors. We sought to evaluate the relationship between medical comorbidities and CR in cognitively normal individuals from ADNI. Methods The sample analyzed included 129 cognitively normal older adults without concerns (CN) and 82 participants with significant memory concern (SMC) from ADNI. In this study, CR was conceptualized as performance residualized for the effect of demographic and brain pathologic factors. We calculated unstandardized residuals from linear regression models evaluating the relationship …

Año de publicación:

2019

Keywords:

    Fuente:

    googlegoogle

    Tipo de documento:

    Other

    Estado:

    Acceso abierto

    Áreas de conocimiento:

    • Neuropsicología
    • Medicina interna

    Áreas temáticas:

    • Fisiología humana
    • Enfermedades
    • Medicina y salud

    Contribuidores:

    Jefferson Michael Acosta OrtizJefferson Michael Acosta Ortiz