P4‐094: EXOME‐WIDE ANALYSIS IDENTIFIES NOVEL SEX‐SPECIFIC CANDIDATE GENES FOR ALZHEIMER DISEASE

Abstract:

Background Women comprise nearly two-thirds of all Alzheimer disease (AD) cases, suggesting gender-specific risk and protective factors. For example, a number of studies have established that apolipoprotein E (APOE) genotype contributes to risk of AD differently in men and women. To identify additional sex-specific genetic associations with AD, we analyzed large case-control whole-exome sequencing (WES) and imputed genome-wide datasets using two complementary statistical analyses. Methods Sex-interaction and sex-stratified analyses were performed for non-Hispanic white subjects in the Alzheimer's Disease Sequencing Project (ADSP) case-control WES study (N= 5,522 cases, 56.4% female; 4,919 controls, 59.1% female) to investigate genetic risk differences between males and females. Sex-interaction analyses used logistic regression with a sex-by-genotype interaction term for single-variants and …

Año de publicación:

2019

Keywords:

Fuente:

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