P4‐101: Anxiety mediates endorsement of subjective cognitive decline questions in non‐demented older adults

Abstract:

Background Subjective cognitive decline (SCD) may pbkp_redict future cognitive decline and diagnostic progression to Alzheimer's disease. Alternatively, the presence of SCD may be influenced by non-cognitive factors, such as anxiety. Thus current SCD assessment methods may lack specificity. The current study examined specific SCD questions and their associations with general anxiety in non-demented older adults. Methods Participants included 1120 cognitively normal (NC; 69±8 years, 56% female) and 250 MCI individuals (76±10 years, 52% female) from the Vanderbilt Memory & Alzheimer's Center participant registry. All completed a telephone-based cognitive screener, medical history, and 196-item SCD survey. Anxiety was defined as endorsing recent or past feelings of anxiety (n= 427). SCD status included the upper tertile of the total SCD score (n= 397, 70±9 years; 57% female). Binary logistic regression …

Año de publicación:

2015

Keywords:

Fuente:

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