P4‐328: HIGHER BASELINE AORTIC PULSE WAVE VELOCITY RELATES TO LONGITUDINAL GREY AND WHITE MATTER CHANGES

Abstract:

Background Age-related vessel wall thickening and elastin loss result in aortic stiffening that contributes to damaging pressure wave propagation and precedes the development of hypertension. Higher aortic pulse wave velocity (PWV), a marker of central arterial stiffening, may contribute to structural brain changes due to repeated cerebral small vessel damage. This study examined whether higher baseline aortic PWV related to longitudinal cerebral grey or white matter changes among older adults. The present study is among the first to examine longitudinal regional cerebral changes due to aortic PWV. Methods Vanderbilt Memory & Aging Project participants free of stroke and dementia at enrollment were examined (n= 279, 73±7 years, 42% female). Aortic PWV (m/sec) was quantified from cardiac magnetic resonance. Multimodal 3T brain MRI included T 1-weighted imaging for assessing grey matter volumes and …

Año de publicación:

2019

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Fuente:

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